Jeanne, in a state of despair, drives aimlessly through the night. She is a doctor, and she believes that she is responsible for the death of a patient and her baby, who were murdered by the woman's husband. At dawn, Jeanne stops in the village of Sainte-Anne-de-Beaupré, site of a famous Catholic shrine, intending to kill herself by jumping into river. However, she is stopped by a young man, François, who has come to the shrine to pray for his grandmother. Something about the enigmatic François touches Jeanne. Not his faith, which puts her off, but his simplicity. François takes Jeanne to his village, hoping that she will treat his grandmother. Nothing is to be done, however, and the old woman dies in her grandson's arms. Her quiet, peaceful death helps Jeanne re-embrace her own existence.