Starlet explores the unlikely friendship between 21 year-old Jane (Dree Hemingway), and 85 year- old Sadie (Besedka Johnson), two women whose worlds collide in California's San Fernando Valley. Jane spends her time getting high with her dysfunctional roommates, Melissa and Mikey, while taking care of her Chihuahua, Starlet. Sadie, an elderly widow, passes her days alone, tending to her flower garden. After a confrontation between the women at Sadie's yard sale, Jane uncovers a hidden stash of money inside a relic from Sadie's past. Jane attempts to befriend the caustic older woman in an effort to solve her dilemma and secrets emerge as their relationship grows.