The second film in the Machete trilogy finds Machete mourning the loss of his beloved Sartana, slain during a run in with the cartels. Machete is recruited by the President of the United States for a mission which would be impossible for any mortal man. Machete must battle his way through Mexico to take down a cartel leader, Mendez the Madman, who threatens to fire a missile on the US. Machete foils Mendez's plot only to find that the missiles are remote wired to and triggered by the madman’s still beating heart. The only man who can disarm the missile is eccentric billionaire arms dealer, Luther Voz, who has hatched a plan of his own to spread war across the planet with a weapon in space. Machete takes on Voz and his army in order dismantle his master plan for global anarchy.