ELLA, a member of the Girl Band Y.E.S, has continued to catch the media's attention due to her scandal involving MANDY's boyfriend. Unfortunately the publicized affair has resulted in MANDY committing suicide and consequently this tragic incident has become a hot topic in town. The other two members of Y.E.S Y and SUGAR are very disappointed by the incident. FEI BA, the manager of Y.E.S, also affected by the scandal. While the situation has fallen into deep depression, the television station top producer COEN ignores the tragic incident that has happened and invites all three members to the brand new V Hotel at Thailand to shoot for a travel program. FEI BA accepts this offer as this could benefit the band from keeping their publicity. In recent years, Bangkok's tourism has been affected by unstable weather and political issues. V Hotel differs from other usual 5-star hotels as it has a PANIC ROOM to deal with these situations. The hotel has not officially opened, ROBERT, the general manager of V Hotel, accompanies the team during shooting and provides them with better understanding of the operation of the hotel. COEN has invited three audiences, SIU LAM, MING LEUNG and WILLIAM and also FENG SHUI Master DRAGON KING to work with Y.E.S in the TV programme, in an effort to create new chemistry. Since arrival, FEI BA has been non-stop sneezing because of his nasal allergy. In addition he has been affected by food poisoning after dining out with the crew, which has caused a skin infection. The doctor informs his situation to the Food and Environmental Hygiene Department, and the department decides to temporarily close down the whole hotel. Everyone is very frustrated and tries to escape or attempts to contact the people outside. Nevertheless none of these actions are successful. Tragically whoever falls in contact with FEI BA will get infected by the new virus and transform into mutants. ROBERT hopes to guide everyone to hide in the PANIC ROOM as he feels guilty about bringing the crew to the unhygienic restaurant. However, no one believes in him. In order to survive, Y even betrayed and abandoned her best partner SUGAR. The whole team is gradually differentiating. On the other hand, MING LEUNG and DRAGON KING try to find ways to escape. They find guns in the vault of the hotel and fight with the infected patients. Unfortunately, DRAGON KING sacrificed himself in order to save MING LEUNG. ROBERT tries hard to lead everyone to the PANIC ROOM but the virus spreads so quick that in the end only ELLA, SIU LAM, MING LEUNG and WILLIAM are able to escape. Nevertheless, the situation on the street is not any better than inside the hotel. While they are deciding where to go, they find out all the incidents are part of a reality show planned by COEN. The whole purpose is to capture the reactions of everyone and to depict the high security of the V Hotel. Thought the story has come to an end, the dead body of Y is found. Who is the murderer?