Jorge, a handsome pharmacist on his 40's with a comfortable and pleasant life, but in reality it is more comfortable and less pleasant than he had thought. He is married to Ruth, his girlfriend at the University, but she doesn't love him as he deserves, so Jorge gets attention from his friends and his motorcycle. Juan, Jorge's nephew, is Ana's boyfriend. Both are planning their year's end trip to Cuba. However, there is a person who is just interested in avoiding Ana and Juan to be together, so he organizes a plan to break their relationship just before the trip to Cuba. Thousands of ups and downs will take place between Madrid and La Habana.