The story started in Cambridge, UK, in the1960’s, where a small group of scientists passionately driving by curiosity was laying the foundations of modern molecular biology. It was in this context that Cesar Milstein invented monoclonal antibodies, a method for producing vast numbers of antibodies of a single specificity. This invention soon became the basis for therapeutic agents that continue transforming the medical sciences landscape. Following from my previous documentary film on the life and philosophy of Nobel Prize winner Cesar Milstein, I propose to make a new documentary film that will detail the evolution of monoclonals from a laboratory technology to agents of change that have impacted multiple areas of the biomedical sciences, and which have formed the basis of modern immunology and biologic therapeutic technologies. The film will weave together the stories, observations, and insights of the key protagonists in this remarkable episode in the history of modern science and it will explore how the development of monoclonal antibody technology is impacting and reshaping mankind’s future.